Methadone clearance may be increased during pregnancy. Several small studies have demonstrated significantly lower trough methadone plasma concentrations and shorter methadone half-lives in women during their pregnancy compared to after their delivery.As with all opioid drugs, it is necessary to adjust the dosing regimen for each patient individual

If you miss doses or don’t take the drug on schedule: Your medication may not work as well or may stop working completely. You may also experience withdrawal symptoms.Hematologic and Lymphatic – reversible thrombocytopenia has been described hinein opioid addicts with chronic hepatitisDa wird schon so mancher davon geträumt gutschrift, die Erg